This book describes step by step guide to mesotherapy. Mesotherapy is a wonderful technique with constant and good results on several pathologies, especially in domains like rheumatology, sports injuries, pains, and vascular diseases. Mesotherapy has been officially recognized by the French Academy of Medicine in 1987 and a diploma is now necessary for the practice of mesotherapy in France. This book consists of 20 chapters, which include history of mesotherapy, mesotherapy equipment, medicines used in mesotherapy, the rebound effect, therapeutic strategy, techniques of injections in mesotherapy, the mesotherapy consultation, the side effects of mesotherapy, the diseases treated with mesotherapy, the pain management, mesotherapy applications in aesthetic, alopecia and mesotherapy (hair loss), vascular pathology and mesotherapy, dermatologic pathology and mesotherapy, mesolift, keloid, and stretch marks. The Indian Society of Mesotherapy (ISM) was later established under the aegis of the International Society of Mesotherapy (ISM). The benefits of mesotherapy are twofold: doctors may easily learn the technique, while patients can have access to efficient and noninvasive medical technique. The nonsurgical aspect of mesotherapy makes it suitable for practice and potential insertion in the training curriculum of doctors hailing from the following specialties as sports medicine, rheumatology, dermatology, and for general practitioners too. This book has no other aim than to provide to my young colleagues a practical and safe way to treat patients.