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This book has been prepared by professionals working in the UK and sets out the principles and practice of EBM in primary care diagnosis. Giving guidance on over 100 symptoms and disorders, the book illustrates the fundamental issues: that the value of a history, examination and investigation depends on the patient's prior probability of disease and on the setting and expertise of the doctor. Many chapters feature "red flags" - elements of the history or examination that should alert us to the possibility of serious disease, which are vital for general practice.