Safe Major Hepatectomy After Preoperative Liver Regeneration: Preoperative PVE, Two-Stage Hepatectomy, ALPPS and Hepatic Vein Deprivation provides both the history and recent topics of major hepatectomy after liver regeneration as well as the basic background of liver regeneration allowing liver surgeons, general surgeons and hepatologists to increase the safety of major hepatectomy in patients suffering from advanced liver disease.

The mortality rate after major hepatectomies is high worldwide and there is a need to establish a strategy for safe major hepatectomies after liver regeneration. This reference provides importance guidance to cutting edge topics including the molecular mechanism of liver regeneration after preoperative portal vein embolization (PVE), two-stage hepatectomy, associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS), as well as the background, technique, and results of hepatic vein occlusion. Using the evaluation of the risk-benefit balance will aid in avoiding post-hepatectomy liver failure and subsequent patient death.

Coverage of the various methods of accelerating regeneration of the hemiliver volume, such as portal vein embolization (PVE), two-stage hepatectomy, associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS), and hepatic vein occlusion.Provides guidance to increase the future liver remnant (FLR) volume as the key to avoid posthepatectomy liver failure and succeeding patients’ death after major hepatectomy.Helps guide the optimal way to program major surgery with decreased risk of liver failure.