This book serves as a practical guide for mental health practitioners working with children and adolescents with chronic medical concerns. It provides key information on current research and the theoretical foundations underlying many evidence-based assessments and interventions. Based on the current literature, readers are given empirically grounded practical guidance on how to assess patients, implement key clinical interventions, and navigate clinical dilemmas that may arise in different situations. The book covers common issues specific to working with young children, school aged-children, and adolescents, as well as particular medical conditions, and how to conceptualize and treat these concerns. Reproducible worksheets are provided to help clinicians apply what they learn to their clinical practice and to better manage common challenges. This readable book will be an invaluable introduction to the junior clinician, as well as a handy resource for the experienced practitioner, who can refer to relevant sections as specific problems arise.